Lichen Planus (Conditions)
Related Content
-
Conditions (26):
skin disorder, dermatitis, Urticaria, and 23 others
skin disorder, dermatitis, Urticaria, skin hypersensitivity, Behcet's Syndrome, Lupus, Mucocutaneous Lymph Node Syndrome, Scleroderma, Scleredema Adultorum, Psoriasis, Eczema, Pruritus, Skin Neoplasms, Keratosis, Acne, Skin Diseases, Infectious, Sweat Gland Diseases, Acanthosis Nigricans, Pigmentation Disorders, keratoacanthoma, Skin Ulcer, Keloid, Pemphigus, Vesicular Skin Diseases, Skin Abnormalities, Dermatitis, Atopic [hide]
-
Groups (18):
Lichen Planus, Eczema, Melanoma, and 15 others
Lichen Planus, Eczema, Melanoma, Beckers Nevus, Lichen Sclerosis, Darier's Disease, Hidradenitis Suppurativa, Granuloma Annulare, Alopecia Areata, Sweet Syndrome, Psoriasis//Psoratic Arthritis, Acne Rosacea, Behcet's Syndrome, Scleroderma, Urticaria, Lupus, Psoriasis, Arthritis [hide]
-
Symptoms (26):
Erythema, Cicatrization, skin hyperplasia, and 23 others
Erythema, Cicatrization, skin hyperplasia, Urticaria, Scleroderma, Angioedema, red skin rash, Hypersensitivity, Immediate hypersensitivity, Granuloma Annulare, Skin Findings, Alopecia Areata, Inflammation, Raynaud's Disease and Phenomenon, Port-Wine Stain, Kallmann Syndrome, Mole, keratinization, Hyperpigmentation, Organic brain syndrome, Discoloration of skin, Skin Manifestations, Sclerodactyly, Alopecia, Fear of cancer of skin, Wernicke-Korsakoff Syndrome [hide]
-
Treatments (26):
Examiner's Diagnosis, Cholecalciferol 400 UNT, Cholecalciferol, and 23 others
Examiner's Diagnosis, Cholecalciferol 400 UNT, Cholecalciferol, Betamethasone 0.0005 MG/MG Topical Gel, Betamethasone 0.0005 MG/MG Topical Ointment, fluocinolone 0.1 MG/ML / hydroquinone 40 MG/ML / Tretinoin 0.5 MG/ML Topical Cream, EUCALYPTUS/MENTHOL/METHYL SALICYLATE/TRIETHANOLAMINE GEL,TOP, Relaxation of scar or web contracture of skin, AQUADERM CREAM, MENTHOL/ZINC OXIDE PWDR,TOP, hydroquinone 40 MG/ML / padimate-O 30 MG/ML Topical Cream, Lactic acid 20 MG/ML / phenol 10 MG/ML / Salicylic Acid 30 MG/ML Topical Lotion, Lactic acid 0.02 MG/MG / phenol 0.01 MG/MG / Salicylic Acid 0.03 MG/MG Topical Ointment, hydroquinone 40 MG/ML Topical Cream, Dermabrasion, TALOIN OINT,TOP, Interferon Alfa-2b, HYDROQUINONE 4 %, BENZOPHENONE-3/PARA-AMINOBENZOIC ACID LOTION, PARA-AMINOBENZOIC ACID LOTION, Other OR therapeutic procedures on skin and breast, dioxybenzone 30 MG/ML / ETHYL DIHYDROXYPROPYL PABA 50 MG/ML / hydroquinone 40 MG/ML Topical Cream, dioxybenzone 0.03 MG/MG / ETHYL DIHYDROXYPROPYL PABA 0.05 MG/MG / hydroquinone 0.04 MG/MG Topical Gel, CARRINGTON DRESSING GEL SPRAY,TOP, CARRINGTON GEL,TOP, FLUOCINOLONE ACETONIDE 0.025 % [hide]
About Lichen Planus
Lichen Planus is an inflammatory disease that affects the skin and the oral mucosa.
Cause
The cause of lichen planus is not known(meant by cell mediated immunity), however there are cases of lichen planus-type rashes (known as lichenoid reactions) occurring as allergic reactions to medications for high... more 
Lichen Planus is an inflammatory disease that affects the skin and the oral mucosa.
Cause
The cause of lichen planus is not known(meant by cell mediated immunity), however there are cases of lichen planus-type rashes (known as lichenoid reactions) occurring as allergic reactions to medications for high blood pressure, heart disease and arthritis. These lichenoid reactions are referred to as lichenoid mucositis (of the mucosa) or dermatitis (of the skin). Lichen planus has been reported as a complication of chronic hepatitis C virus infection. It has been suggested that true lichen planus may respond to stress, where lesions may present on the mucosa or skin during times of stress in those with the disease. Lichen planus affects women more than men 3:2, and occurs most often in middle-aged adults. Lichen planus in children is rare.
Clinical features
The typical rash of lichen planus is well-described by the "5 P's": well-defined pruritic, planar, purple, polygonal papules. The commonly affected sites are near the wrist and the ankle. The rash tends to heal with prominent blue-black or brownish discoloration that persists for a long time. Besides the typical lesions, many morphological varieties of the rash may occur. The presence of cutaneous lesions is not constant and may wax and wane over time. Oral lesions tend to last far longer than cutaneous lichen planus lesions.
Oral lichen planus may present in one of three forms.
* The reticular form is the most common presentation and manifests as white lacy streaks on the mucosa (known as Wickham's striae) or as smaller papules (small raised area). The lesions tend to be bilateral and are asymptomatic. The lacy streaks may also be seen on other parts of the mouth, including the gingiva (gums), the tongue, palate and lips.
* The bullous form presents as fluid-filled vesicles which project from the surface.
* The erosive form presents with erythematous (red) areas that are ulcerated and uncomfortable. The erosion of the thin epithelium may occur in multiple areas of the mouth, or in one area, such as the gums, where they resemble desquamative gingivitis. Wickham's striae may also be seen near these ulcerated areas. This form may undergo malignant transformation.
The microscopic appearance of lichen planus is pathognomonic for the condition
* Hyperparakeratosis with thickening of the granular cell layer
* Development of a "saw-tooth" appearance of the rete pegs
* Degeneration of the basal cell layer
* Infiltration of inflammatory cells into the subepithelial layer of connective tissue
Lichen planus may also affect the genital mucosa - vulvovaginal-gingival lichen planus. It can resemble other skin conditions such as atopic dermatitis and psoriasis.
Rarely, lichen planus shows esophageal involvement, where it can present with erosive esophagitis and stricturing. It has also been hypothesized that it is a precursor to squamous cell carcinoma of the esophagus.[citation needed]
Clinical experience suggests that Lichen planus of the skin alone is easier to treat as compared to one which is associated with oral and genital lesions.
Differential Diagnosis
The clinical presentation of lichen planus may also resemble other conditions, including:
* Lichenoid drug reaction
* Discoid Lupus Erythematosus
* Chronic Ulcerative Stomatitis
* Pemphigus Vulgaris
* Benign Mucous Membrane Pemphigoid
* Oral leukoplakia
* Fricional keratosis
A biopsy is useful in identifying histological features that help differentiate lichen planus from these conditions.
Cause
The cause of lichen planus is not known(meant by cell mediated immunity), however there are cases of lichen planus-type rashes (known as lichenoid reactions) occurring as allergic reactions to medications for high blood pressure, heart disease and arthritis. These lichenoid reactions are referred to as lichenoid mucositis (of the mucosa) or dermatitis (of the skin). Lichen planus has been reported as a complication of chronic hepatitis C virus infection. It has been suggested that true lichen planus may respond to stress, where lesions may present on the mucosa or skin during times of stress in those with the disease. Lichen planus affects women more than men 3:2, and occurs most often in middle-aged adults. Lichen planus in children is rare.
Clinical features
The typical rash of lichen planus is well-described by the "5 P's": well-defined pruritic, planar, purple, polygonal papules. The commonly affected sites are near the wrist and the ankle. The rash tends to heal with prominent blue-black or brownish discoloration that persists for a long time. Besides the typical lesions, many morphological varieties of the rash may occur. The presence of cutaneous lesions is not constant and may wax and wane over time. Oral lesions tend to last far longer than cutaneous lichen planus lesions.
Oral lichen planus may present in one of three forms.
* The reticular form is the most common presentation and manifests as white lacy streaks on the mucosa (known as Wickham's striae) or as smaller papules (small raised area). The lesions tend to be bilateral and are asymptomatic. The lacy streaks may also be seen on other parts of the mouth, including the gingiva (gums), the tongue, palate and lips.
* The bullous form presents as fluid-filled vesicles which project from the surface.
* The erosive form presents with erythematous (red) areas that are ulcerated and uncomfortable. The erosion of the thin epithelium may occur in multiple areas of the mouth, or in one area, such as the gums, where they resemble desquamative gingivitis. Wickham's striae may also be seen near these ulcerated areas. This form may undergo malignant transformation.
The microscopic appearance of lichen planus is pathognomonic for the condition
* Hyperparakeratosis with thickening of the granular cell layer
* Development of a "saw-tooth" appearance of the rete pegs
* Degeneration of the basal cell layer
* Infiltration of inflammatory cells into the subepithelial layer of connective tissue
Lichen planus may also affect the genital mucosa - vulvovaginal-gingival lichen planus. It can resemble other skin conditions such as atopic dermatitis and psoriasis.
Rarely, lichen planus shows esophageal involvement, where it can present with erosive esophagitis and stricturing. It has also been hypothesized that it is a precursor to squamous cell carcinoma of the esophagus.[citation needed]
Clinical experience suggests that Lichen planus of the skin alone is easier to treat as compared to one which is associated with oral and genital lesions.
Differential Diagnosis
The clinical presentation of lichen planus may also resemble other conditions, including:
* Lichenoid drug reaction
* Discoid Lupus Erythematosus
* Chronic Ulcerative Stomatitis
* Pemphigus Vulgaris
* Benign Mucous Membrane Pemphigoid
* Oral leukoplakia
* Fricional keratosis
A biopsy is useful in identifying histological features that help differentiate lichen planus from these conditions.
Loading... thanks for waiting
Loading... thanks for waiting
Loading... thanks for waiting
There was a problem loading an application. Please try refreshing your browser.
Loading... thanks for waiting
