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About Hailey-Hailey disease

Familial benign pemphigus originally was described by the Hailey brothers in 1939, and is commonly called Hailey-Hailey disease. It is characterized by outbreaks of rashes and blisters in the skin, usually in the folds of the skins, but also often over large areas of the body. The painful blisters break... more

Familial benign pemphigus originally was described by the Hailey brothers in 1939, and is commonly called Hailey-Hailey disease.

It is characterized by outbreaks of rashes and blisters in the skin, usually in the folds of the skins, but also often over large areas of the body. The painful blisters break and sometimes become infected and raw, with new blisters forming over raw skin in a sometimes seemingly unending cycles of outbreaks.

The cause of the disease is a defect in the calcium pump ATP2C1 gene which is located on chromosome 3. This causes the cells of the skin to not adhere together properly, causing the blisters and rashes. There is no cure.

Steroidal cremes have some effect during outbreaks, but do not stop them. Avoiding heat and friction of affected areas and keeping the area clean and dry work about as well.

Some have found relief in laser surgery that apparently burns off the top layer of the dermis, allowing healthy non-affected skin to regrow in its place, but this method of treatment is new to the disease and lacks the tests of time.

Unfortunately, there is not much that really helps when the outbreaks come, except to suffer through them, "suffer" being the key word here, since the outbreaks are often extremely painful.

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